I always use Shout spray for treating stains before laundering, but I recently learned how effective it is for set-up stains.
While on a 15-day tour of Scandanavia, I got a bloodstain of one of my garments on the third day of the tour. We didn't have time or the ability to access laundry services, so I just placed the item in the dirty laundry bag where it remained for the next several days. When I returned home, I sprayed the stain with Shout but was very skeptical that the stain would be removed. Imagine my surprise when I discovered that the two-week old stain washed right out after being treated with Shout prior to laundering! Shout is my go-to stain remover from now on!